The Argentina internationals, who completed their moves to the club this week, will both travel with Ustari almost certain to be on the bench.
Steven Fletcher could return to the starting line-up having shown no adverse reaction to the Achilles problem which prevented him from starting against Southampton on Saturday.
However defender Carlos Cuellar (hip) and keeper Keiren Westwood (shoulder surgery) are still out.
Sunderland currently lead United in the tie, having beat David Moyes' side 2-1 in the first-leg at the Stadium of Light.
Sunderland provisional squad: Mannone, Ustari, Pickford, Celustka, Dossena, Alonso, Bardsley, O'Shea, Brown, Vergini, Diakite, Roberge, Cattermole, Gardner, Ki, Giaccherini, Johnson, Larsson, Ba, Karlsson, Mavrias, Colback, Fletcher, Altidore, Borini.